Targeted expression of Vitreoscilla hemoglobin improves the production of tropane alkaloids in Hyoscyamus niger hairy roots
نویسندگان
چکیده
منابع مشابه
Heterologous expression of Vitreoscilla hemoglobin (VHb) and cultivation conditions affect the alkaloid profile of Hyoscyamus muticus hairy roots.
Fast-growing hairy root cultures of Hyoscyamus muticus induced by Agrobacterium rhizogenes offer a potential production system for tropane alkaloids. Oxygen deficiency has been shown to limit growth and biomass accumulation of hairy roots, whereas little experimental data is available on the effect of oxygen on alkaloid production. We have investigated the effect of Vitreoscilla hemoglobin (VHb...
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Background and objectives: Hyoscyamus reticulatus contains two distinguished tropane alkaloids, hyoscyamineand scopolamine and both of the compounds possesspotential acute or chronic toxicity. In the present study, a simple and efficient transformation system was established for in vitro hairy roots induction in Hyoscyamus reticulatus. M...
متن کاملAssessment of Morphological and Tropane Alkaloids Diversity among some Henbane (Hyoscyamus niger L.) Populations
Background: Black henbane with the scientific name of Hyoscyamus niger which has a wide geographic distribution, is considered as one the most important species for tropane alkaloids extraction. Objective: In this research, morphological and tropane alkaloids variations were assessed within different population of H. niger in their natural habitats. Methods: Totally, 56 individuals were colle...
متن کاملThe effects of fungal and yeast elicitors on the production of tropane alkaloids in Hyoscyamus niger plantlets under in vitro condition
Henbane (Hyoscyamus niger) is a perennial herbaceous plant of the Solanaceae family that like to other plants of this family such as Atropa and Datura produces pharmaceutical tropane alkaloids hyoscyamine and scopolamine. These medicinal valuable compounds have anticholinergic effects, and antispasmodic and sedative properties. One of the most cost-effective strategies to increase production of...
متن کاملChanges of Tropane Alkaloids in Black Henbane (Hyoscyamus niger L.) in Response to Different Types of Nitrogenous Fertilizers
Background: Since alkaloids are nitrogenous compounds, the availability of nitrogen (N) is expected to play an important role in the biosynthesis and accumulation of alkaloids in plants. Nitrogen has been found to increase the content of alkaloids in some of the medicinal plants. Objective: The aim of this study was to compare the effects of nitrogen bio-fertilizers, conventional nitrogen fe...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-36156-y